Conformational properties of the octanucleotide d(pG-A-T-C-T-T-T-T) and its intermediates.
نویسندگان
چکیده
In studies of some sequence dependent structural factors and stabilizing effects of oligonucleotides the octanucleotide d(pG-A-T-C-T-T-T-T) was of particular interest in view of the presence of an endonuclease cleavage site. Its chemical synthesis is reported as well as the structural effects in CD spectral properties of the octanucleotide and of some related compounds.
منابع مشابه
Chemical synthesis of a self-complementary octanucleotide, dG-G-T-T-A-A-C-C by a modified triester method.
The synthesis of a self-complementary octanucleotide, d(G-G-T-T-A-A-C-C-), using a modified triester approach is described. The protected dinucleotides, d(Me2O)TribG(C1C6H4) ibG, d(Me2O)TrT(ClC6H4)T, d(Me2O)TrbzA(ClC6H4)bzA, and d(Me2O)TranC(ClC6H4)anC were synthesized by a one step triester procedure. After removal of the trityl group, the dinucleotides, dT(ClC6H4)T and danC (ClC6H4)anC were c...
متن کاملAmitraz Poisoning; A case study
A m i t r a z, a n i ns e c t i c i d e /a ca ri c i de of the f o r m a m i d i n e p e st i c i d e s group, is a ? 2 a d r e n e r g i c ag on i st a nd of t he a m i d i ne c h e m i ca l f a m il y generally us e d to c o n t r ol animal e c top a r a s i t e s. Poisoning due to am i t r a z i s r a r e and character...
متن کاملBilateral composition operators on vector-valued Hardy spaces
Let $T$ be a bounded operator on the Banach space $X$ and $ph$ be an analytic self-map of the unit disk $Bbb{D}$. We investigate some operator theoretic properties of bilateral composition operator $C_{ph, T}: f ri T circ f circ ph$ on the vector-valued Hardy space $H^p(X)$ for $1 leq p leq +infty$. Compactness and weak compactness of $C_{ph, T}$ on $H^p(X)$ are characterized an...
متن کاملPioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats
Objective(s): Testicular torsion/detorsion (T/D) is a well-known cause for infertility. Pioglitazone is an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ). Previous studies have shown that pioglitazone has anti-inflammatory, antioxidant and antiapoptotic properties. The present study hypothesized that pioglitazone may be protective against the test...
متن کاملO 1: The Effects of Vitamin D Supplementation on the T cell Compartment in Multiple Sclerosis
Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Nucleic acids research
دوره 6 2 شماره
صفحات -
تاریخ انتشار 1979